Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion): A Narrative Review

Background: Bizarre parosteal osteochondromatous proliferation (BPOP), or Nora lesion, is a rare proliferative disease arising from the region of bones. Although BPOP’s pathogenesis still not certain, modern literature suggests it to be tumor-like lesion even benign neoplasm. Due extremely low incidence, this date studies on topic are limited case reports and few series. This narrative review aims resume BPOP provide an overview its natural history, morphologic characteristics prognostic horizon.Materials methods: A systematic research was done identify reporting patients who suffered between 1983 2021. We collected data regarding aetiologic pathogenetic theories, patients’ personal anamnesis, lesions’ location, clinical presentation, imaging features, pathological appearance, treatment prognosis.Results: identified 322 cases with mean age 34.3 years at moment diagnosis. There no gender difference. The most involved site hand, followed by foot. history trauma reported for 14.7% cases. 38.7% had pain. Literature defined typical radiographic microscopic patterns that characterize lesions. While fundamental orientate towards BPOP, histological evaluation mandatory get definitive To date, only reliable therapeutic option represented surgical resection. burdened risk recurrence accounts 37.4%.Conclusion: should considered during differential diagnosis lesions, especially in acral regions. Careful diagnostic evaluations necessary correct wide margins resection recommended minimize relatively high local recurrence.